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Tuesday, August 11, 2020 | History

2 edition of Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel. found in the catalog.

Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel.

Ishtiaq Ahmed

Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel.

by Ishtiaq Ahmed

  • 330 Want to read
  • 34 Currently reading

Published .
Written in English


About the Edition

Immunohistochemical and electrophysiological characterization of alpha- and beta-cells confirmed the viability of the GFP-labelling technique for examining islet cells. Furthermore, we demonstrated a large variance in beta-cell sizes with potential functional consequences.Pancreatic islet alpha- and beta-cells secrete glucagon and insulin respectively to maintain glucose homeostasis. Study of alpha-cells is limited by difficulties in isolating and identifying them and therefore little is known concerning regulation of alpha-cell membrane excitability and exocytosis. This thesis (1) assesses a new technique for efficient detection of alpha-cells in a transgenic mouse model expressing GFP-labelled beta-cells and (2) subsequently studies the alpha-cell Kv4.3 channel and its potential regulation by syntaxin 1A (Syn1A), a SNARE protein involved in modulating cell excitability and exocytosis.Our results also indicate that Kv4.3, which significantly shapes action potentials, is less responsive to Syn1A induced inhibition than other Kv channels and that Syn1A - Kv interactions are diverse and dynamic in nature.

The Physical Object
Pagination130 leaves.
Number of Pages130
ID Numbers
Open LibraryOL19215949M
ISBN 109780494163900


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Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel by Ishtiaq Ahmed Download PDF EPUB FB2